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GLP-1 Receptor Agonists at the Crossroads of Circadian Biology, Sleep, and Metabolic Disease
Though several molecules, such as mazdutide, a GLP/glucagon dual agonist, are being studied in various phases, the first agent targeting incretins other than just GLP-1 was approved in 2022 – tirzepatide [41]
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IL-1β similarly compromises myocardial contractile function and triggers activation of the NOD-like receptor protein 3 (NLRP3) inflammasome, a key intracellular protein complex that further amplifies inflammatory responses [91]
Collagen is the most abundant protein in the body and is a key constituent of all connective tissues
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